Table 5.
Survival probabilities estimated through the Cox regression modeling in four risk groups of progressing patients.
| Risk Groups | Baseline Biomarkers | Overall Survival | p-Value | ||
|---|---|---|---|---|---|
| HR | 95% CI | ||||
| cfDNA | CTCs | 0.007 | |||
| 1 | ≤836.5 | ≤2 | 1.00 | (Ref.) | |
| 2 | >2 | 1.98 | 0.80–4.90 | ||
| 3 | >836.5 | ≤2 | 4.08 | 1.55–10.71 | |
| 4 | >2 | 8.09 | 2.06–31.71 | ||
The risk subgroups were identified by cross-classifying patients according to the two categories of both biomarkers (CTCs: ≤ 2 and > 2; cfDNA: ≤ 836.5 and > 836.5). 1—low (Reference category; Ref.): 15 patients; 2—low-intermediate: 8 patients; 3—high-intermediate: 8 patients; 4—high: 5 patients; HR: hazard ratio; 95% CI: 95% confidence intervals for HR. p-value: probability level associated with the likelihood ratio test.