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. 2019 Jun 28;11(7):910. doi: 10.3390/cancers11070910

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TSA is shown to increase body weight and decrease Serum LDH, creatine kinase of muscle-brain type (CKMB), and apoptosis in mice. (A) TSA increased body weights compared with the model group (n = 10). TSA decreased Serum LDH (n = 8) (B) and CKMB (n = 8) (C) compared with the model group. (D) TUNEL results showed that TSA was able to decrease the apoptosis rate (n = 5). Scale bar: 50 μm. (E) TSA regulated the expression of apoptosis-related proteins, including Bcl-2 and Bax, and the results showed that TSA treatment upregulated the expression of Bcl-2 and downregulated the expression of Bax (n = 5). All data are presented as mean ± SD. * p < 0.05 is significantly different as indicated, for values in the model group. LDH, abbreviation of lactate dehydrogenase; TUNEL, abbreviation of Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; DAPI, abbreviation of 4′,6-diamidino-2-phenylindole.