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. 2019 Jul 11;8(7):704. doi: 10.3390/cells8070704

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Decreased intracellular pH in response to acidic extracellular pH in wild-type and Tg737 cells. (a,b) Representative tracings of changes in intracellular pH_i when wild-type and Tg737 cells are exposed to media of decreasing extracellular pH (pH_o) from 7.4 to 5.5. (c) As the pH_o is decreased, both cell lines show a similar decrease in their pH_i. (d) The rate constant pH_i changes (ΔpH_i) in response step changes in pH_o are also similar in both cell lines. A negative value indicates a decrease in pH_i. (e) Changes in ΔpH_i (ΔΔpH_i) are normalized to identify variability within ΔpH_i in response to step changes in pH_o. No variation is observed if there is no acceleration or deceleration (first order kinetic or ΔΔpH_i = 0). Highest variation (ΔΔpH_i = 100) indicates that an alternate acceleration-deceleration pattern occurred (if acceleration = deceleration, then ΔpH_i = 0).

Decreased intracellular pH in response to acidic extracellular pH in wild-type and Tg737 cells. (a,b) Representative tracings of changes in intracellular pH_i when wild-type and Tg737 cells are exposed to media of decreasing extracellular pH (pH_o) from 7.4 to 5.5. (c) As the pH_o is decreased, both cell lines show a similar decrease in their pH_i. (d) The rate constant pH_i changes (ΔpH_i) in response step changes in pH_o are also similar in both cell lines. A negative value indicates a decrease in pH_i. (e) Changes in ΔpH_i (ΔΔpH_i) are normalized to identify variability within ΔpH_i in response to step changes in pH_o. No variation is observed if there is no acceleration or deceleration (first order kinetic or ΔΔpH_i = 0). Highest variation (ΔΔpH_i = 100) indicates that an alternate acceleration-deceleration pattern occurred (if acceleration = deceleration, then ΔpH_i = 0).