Table 2.
Gene expression in CTCs in respect to DFI and OS.
| Gene Expression in CTCs | DFI | OS | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Mean Survival | 95% CI (months) | Range (months) | p | Mean Survival | 95% CI (Months) | Range (Months) | p |
| TWIST1+ | 83.6 | 61.9–105.3 | 9–125 | 0.019 | 106.4 | 90.3–122.3 | 16–127 | 0.046 |
| TWIST1− | 115 | 106.3–125.2 | 4–137 | 127.2 | 120.7–133.7 | 6–137 | ||
| Stem cell profile positive (SC+) | 86.7 | 66.7–106.8 | 16–118 | 0.174 | 107.3 | 89.8–124.8 | 26–127 | 0.171 |
| Stem cell profile negative (SC−) | 113.2 | 103.5–122.8 | 4–137 | 125.2 | 118.3–132.1 | 6–137 | ||
| TWIST1+/SC+ | 68.9 | 39.4–98.31 | 16–112 | 0.087 | 96.2 | 67.4–125.1 | 26–127 | 0.118 |
| TWIST1+/SC− | 88.8 | 61.2–116.4 | 9–125 | 111.1 | 93.3–128 | 16–125 | ||
| TWIST1−/SC+ | 100.1 | 78.6–121.7 | 41–118 | 109.1 | 92.8–125.3 | 47–118 | ||
| TWIST1−/SC− | 115.8 | 105.8–126 | 4–137 | 127.3 | 120.4–134.2 | 6–137 | ||
| TWIST1+/LN+ | 82.6 | 59.3–105.9 | 9–125 | 0.05 | 108.8 | 93–124.6 | 16–127 | 0.194 |
| TWIST1+/LN− | 88.7 | 30.5–146.8 | 16–125 | 92 | 39.1–144.8 | 26–125 | ||
| TWIST1−/LN+ | 110.3 | 99.2–121.4 | 6–130 | 121.3 | 113–129.6 | 6–130 | ||
| TWIST1−/LN− | 123.3 | 110.6–135.9 | 4–137 | 128.9 | 120.2–137.7 | 37–137 | ||
| TWIST1+/N2–3 | 68.6 | 40.5–96.7 | 9–125 | 0.007 | 98.3 | 75.5–121.2 | 16–127 | 0.026 |
| TWIST1+/N1 | 104.5 | 71.8–137.5 | 13–123 | 112 | 94–125 | 101–118 | ||
| TWIST1−/N2-3 | 103.1 | 84.1–121.9 | 6–130 | 118.8 | 103.4–134.1 | 6–130 | ||
| TWIST1−/N1 | 114.4 | 101.7–126.9 | 9–128 | 121.1 | 111.9–130.3 | 30–128 | ||
| TWIST1+/HR+ | 102.3 | 81.2–123.4 | 9–125 | <0.001 | 121.6 | 113.9–129.3 | 79–127 | <0.001 |
| TWIST1+/HR− | 36 | 8.9–63 | 10–106 | 65.7 | 36.7–94.6 | 76–106 | ||
| TWIST1−/HR+ | 117.9 | 107.1–128.7 | 4–137 | 131.9 | 126.2–137.5 | 37–137 | ||
| TWIST1−/HR− | 107.7 | 92.3–123.1 | 6–127 | 110.2 | 96.5–123.84 | 6–127 | ||
Bold: highlights the significance of the test.