. 2019 Jun 29;8(7):652. doi: 10.3390/cells8070652

Table 3.

Univariate and multivariate analyses for DFI and OS in the early breast cancer patients group (n = 100).

Covariates	Covariate Value	DFI						OS
		Univariate Cox Regression Analysis			Multivariate Cox Regression Analysis			Univariate Cox Regression Analysis			Multivariate Cox Regression Analysis
		HR ^a	95% CI ^b	p	HR ^a	95% CI ^b	p	HR^a	95% CI^b	p	HR ^a	95% CI ^b	p
Age	≥50 vs <50	0.787	0.357–1.734	0.552	0.432	0.169–1.103	0.079	0.718	0.249–2.070	0.539	0.593	0.169–2.080	0.414
ER	Yes vs No	0.647	0.286–1.463	0.295	4.391	1.040–18.549	0.044	0.238	0.079–0.721	0.011	0.623	0.092–4.215	0.628
PR	Yes vs No	0.492	0.217–1.114	0.089	0.087	0.021–0.362	0.001	0.196	0.054–0.707	0.013	0.098	0.011–0.851	0.035
HER2	Yes vs No	0.500	0.197–1.269	0.145	0.626	0.232–1.693	0.357	0.381	0.106–1.366	0.139	0.247	0.060–1.023	0.054
Lymph nodes	N₀ vs N₁ vs N_2–3	2.207	1.261–3.861	0.006	2.433	1.272–4.654	0.007	1.659	0.817–3.371	0.162	1.351	0.637–2.862	0.433
Size	≥2cm vs <2cm	3.060	1.049–8.922	0.041	4.926	1.225–19.811	0.025	7.244	0.947–55.432	0.056	17.450	1.464–208.1	0.024
Grade	I/II vs III	1.366	0.570–3.273	0.485	0.753	0.228–2.483	0.641	1.953	0.544–7.008	0.305	0.286	0.040–2.028	0.211
TWIST1	Yes vs No	2.582	1.135–5.875	0.024	1.382	0.490–3.899	0.540	2.851	0.975–8.33	0.051	1.481	0.382–5.743	0.570
HR and TWIST1 status	HR+TWIST1+	0.486	0.302–0.784	0.003	0.597	0.360–0.991	0.046 ^c	0.576	0.313–1.062	0.077	0.666	0.345–1.284	0.225^c
	HR+TWIST1-
	HR-TWIST1+
	HR-TWIST1-
LN and TWIST1 status	N_0-1TWIST1+	0.540	0.383–0.762	<0.001	0.542	0.371–0.792	0.002 ^d	0.559	0.357–0.875	0.011	0.604	0.373–0.976	0.040 ^d
	N_0-1TWIST1-
	N_2-3TWIST1+
	N_2-3TWIST1-
Stem cell profile	Yes vs No	1.873	0.746–4.703	0.181	1.755	0.526–5.855	0.360	2.206	0.690–7.050	0.182	3.689	0.806–16.884	0.093
Stem cell profile/TWIST1+	Yes vs No	0.663	0.473–0.929	0.017	0.776	0.521–1.146	0.202^e	0.624	0.402–0.967	0.035	0.634	0.378–1.065	0.085^e

^a Hazard ratio, estimated from Cox proportional hazard regression mode. ^b Confidence interval of the estimated HR. Results are based on 1000 bootstrap samples and obtained after the Bias corrected and accelerated (BCa) approach. ^c Multivariate model adjusted for age, HER2, LN, Size, Grade, Stem cell. ^d Multivariate model adjusted for age, ER, PR, HER2, Size, Grade, Stem cell. ^e Multivariate model adjusted for age, ER, PR, HER2, LN, Size, Grade. Bold: highlights the significance of the test.