Figure 3.

Changes in cellular functions by repression and re-expression of LSR. Under normal growth conditions, LSR localized in tricellular contacts in primary cultured normal human endometrial cells and Sawano cells. The knockdown of LSR enhanced cell motility and cell growth accompanying with decrease in barrier function. Leptin suppressed LSR expression; in contrast, adiponectin induced an increase in its expression. AMPK activator metformin and berberine also induced an increase in LSR expression at the subapical region of tricellular contacts, resulting in the rescue of the LSR-knockdown phenotypes.