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Proposed work-up and treatment plan of LAPC. * Diagnostic laparoscopy can be performed either prior to the start of induction chemotherapy or prior to explorative laparotomy; ** Since randomized studies confirming the efficacy of ablation in LAPC are lacking, patients should only be treated within the context of clinical trials; BSC: best-supportive care; LAPC: locally advanced pancreatic cancer; (B)RPC: borderline resectable pancreatic cancer.
