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. 2019 Jul 9;12(7):dmm037994. doi: 10.1242/dmm.037994

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — CCh induces an extreme slowing of spontaneous beating in S81L^homo hiPSC-CMs, which is largely suppressed by I_K,ACh blockade through XEN-R0703. (A) Typical APs of an S81L^homo hiPSC-CM at baseline (top), upon application of 10 µmol l⁻¹ CCh (middle), and upon addition of 1 µmol l⁻¹ XEN-R0703 in the presence of 10 µmol l⁻¹ CCh (bottom). (B) Effects of CCh and XEN-R0703 on spontaneous AP frequency in four S81L^homo hiPSC-CMs. *P<0.05 (one-way repeated measures ANOVA followed by post-hoc Holm-Sidak test). XEN-R0703 restores the beating frequency of S81L^homo hiPSC-CMs to values similar to a baseline condition.