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. 2019 Jul 9;12(7):dmm037994. doi: 10.1242/dmm.037994

Fig. 6.

Fig. 6.

ACh induces more pronounced effects in S81Lhomo compared to WT human SAN pacemaker cells in computer simulations. (A-C) Spontaneous APs (blue lines) and associated net membrane current (Inet, gray lines), hyperpolarization-activated ‘funny current’ (If, green lines) and IK,ACh (red lines) in a WT human SAN pacemaker cell at baseline (A), upon addition of 10 nmol l−1 ACh (B) and upon addition of 10 nmol l−1 ACh in the presence of XEN-R0703 (C). (D-F) Spontaneous APs and associated Inet, If and IK,ACh in an S81Lhomo human SAN pacemaker cell at baseline (D), upon addition of 10 nmol l−1 ACh (E) and upon addition of 10 nmol l−1 ACh in the presence of XEN-R0703 (F).