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. 2019 Jul 16;12(7):dmm038810. doi: 10.1242/dmm.038810

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Profibrogenic markers in livers from wild-type and Irs2-deficient mice after BDL. (A) Representative images (20×) of liver sections after H&E and Sirius Red staining. (B) Sirius Red fibrosis score. (C) Serpine1 mRNA levels determined by RT-qPCR. (D) Serum bilirubin and alkaline phosphatase (ALP) levels. (E) Col1a1 and Acta2 mRNA levels determined by RT-qPCR. Wild-type (WT) and Irs2-deficient (IRS2KO) female mice were submitted to BDL or sham operated and analyzed at the indicated time periods (28 days after BDL in A–D). Statistical significance was assessed by one-way ANOVA with Bonferroni post-test: *P<0.05, BDL versus sham; ^#P<0.05, IRS2KO versus WT (n=6–8 animals per condition).