Fig. 5.

Posturo-locomotor alterations and alterations of the general behaviour following TTK administration. Evolution of vestibular alteration over time in TTK-treated, UVN-operated and sham mice during the 2 min evaluation. (A) Vestibular signs and (B) general behaviour in the open field. (C) Swim deficit score in the pool. (D) Postural alterations during the tail-hanging landing paradigm. Results are expressed as mean±s.e.m. The sham mice are represented by open circles, the TTK-treated mice by dark triangles and the UVN-operated mice by grey squares (n=9 in each group). Repeated measures ANOVA followed by Bonferroni post-hoc analyses were used to observe TTK administration effects (i.e. TTK vs sham mice): **P<0.01; ***P<0.001. We performed a repeated measures ANOVA followed by Bonferroni post-hoc analyses to observe treatment effects (i.e. TTK vs UVN): ^§P<0.001, ^(§)P=0.06.