Fig. 2.

Deregulated MYC transforms breast acini into invasive breast carcinoma in vivo. (A) Tumours harvested in Figure 1C were stained (above) for Ki67 and TUNEL and were quantified (below) for the degree of Ki67 and TUNEL staining. Individual quantifications per tumour are shown; *P≤0.05, ***P≤0.001, one-way ANOVA with Bonferroni post-test for multiple testing. Scale bar: 100 μm. (B) Tumours harvested in Figure 1C were stained for ER, PR, HER2, CK5, EGFR, p63 and SMA by the Pathology Research Program Laboratory. (C) A pathology report was produced for each tumour using a combination of H&E, as shown in Figure 1D, and IHC markers used in this study. Scale bar: 100 μm.