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. 2019 Jul 26;12(7):dmm038737. doi: 10.1242/dmm.038737

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Time course of respiratory chain complex IV and citrate synthase functional impairment in TgHD minipig skeletal muscle during the development of HD. (A) Specific activity of the respiratory chain complex IV (COX) is significantly reduced in TgHD animals in comparison with WT animals (P=0.0271). (B) Complex IV (CIV)-dependent respiration was significantly decreased in TgHD animals (P=0.0003). (C) The ratio of respiratory parameters CI/CIV is significantly increased in the TgHD group, which may indicate reduced functionality of RCCIV in TgHD animals (P=0.0164). (D) The activity of citrate synthase is significantly reduced in TgHD animals (P=0.0171). Analyses were performed with samples collected at the ages of 24, 36, 48 and 66 months. In the box-whisker plots, median and quartiles are displayed. Circles represent outliers that are further than 1.5IQR from the corresponding quartile. Whiskers show the range of non-outliers. Boxes represent the TgHD and WT groups that consist of all animals in all ages between 24 and 66 months; numbers of analyzed samples are indicated. Enzyme activities were measured spectrophotometrically and respiration was measured by high-resolution respirometry using an OROBOROS oxygraph.