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. 2019 Jul 26;12(7):dmm038737. doi: 10.1242/dmm.038737

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Decreased function of respiratory chain complex I in TgHD minipig skeletal muscle during the development of HD. (A) Activity of complex I+III (NCCR, NADH:cytochrome c reductase) is significantly decreased (P=0.0249) in TgHD muscle. (B) Complex I-dependent respiration (GM) is significantly decreased in TgHD animals (P=0.0321). Analyses were performed with samples collected at the ages of 24, 36, 48 and 66 months. In the box-whisker plots, median and quartiles are displayed. Circles represent outliers that are further than 1.5IQR from the corresponding quartile. Whiskers show the range of non-outliers. Boxes represent the TgHD and WT groups that consist of all animals in all ages between 24 and 66 months; numbers of analyzed samples are indicated. Enzyme activities were measured spectrophotometrically and respiration was measured by high-resolution respirometry on an OROBOROS oxygraph.