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. 2019 Jun 10;8(7):bio042192. doi: 10.1242/bio.042192

Fig. 3.

Fig. 3.

Expression of CYP metabolizing enzyme genes in differentiated hiPS cells on the collagen vitrogel or nanofiber matrices or 2D plates. Expression levels of various metabolizing enzymes were quantified by real-time PCR in undifferentiated hiPS cells (iPS) or hiPS-hep, grown on tissue culture plates pre-coated with SynthemaxII (2D), nanofiber (pre-coated with Matrigel; NF) or the CV membranes. Primary hepatocytes (PH, 0 h) were used as a reference. For differentiated hiPS cells, values represent means±s.d. (n=3). Relative values are shown, with the value of D42 hiPS cells grown on the CV=1. *P<0.05 or **P<0.01, by two tailed Student's t-test, compared between hiPS-hep grown on CV (D31) versus NF (D30); or CV (D31) versus CV (D42).