Table 3.
Pathologic Diagnoses in 626 Patients with Clinical Diagnosis of AD. The majority of clinical AD cases as observed in the Mayo Clinic Brain Bank from 2007 to 2016 were found to have co-pathologies. Plus sign (+) in the column on pathological diagnosis of AD indicates additional pathologies beyond the primary and secondary diagnoses listed. Secondary AD indicates a primary pathological diagnosis other than Alzheimer’s disease though AD changes are noted and contributing. Bold indicates significance differences from the pure AD cases (Student t-Test, p < 0.01)
| Path Dx | Cases (n) | Age (yr) | Brain (g) | Braak | Thal |
|---|---|---|---|---|---|
| AD | 108 | 77.3 ± 11.2 | 1060 ± 166 | 5.6 ± 0.7 | 4.7 ± 0.7 |
| AD/LBD | 73 | 79.2 ± 9.7 | 1017 ± 122 | 5.7 ± 0.5 | 4.9 ± 0.5 |
| AD/LBD+ | 104 | 83.1 ± 8.3 | 981 ± 168 | 5.6 ± 0.6 | 4.8 ± 0.6 |
| AD/Vas | 41 | 84.4 ± 5.0 | 1007 ± 148 | 5.4 ± 0.8 | 4.6 ± 0.7 |
| AD/Vas+ | 46 | 86.9 ± 6.6 | 1052 ± 135 | 5.2 ± 0.6 | 4.8 ± 0.5 |
| AD/CAA | 17 | 75.3 ± 14.8 | 1019 ± 146 | 5.8 ± 0.4 | 4.8 ± 0.4 |
| AD/CAA+ | 53 | 80.3 ± 9.1 | 1045 ± 156 | 5.6 ± 0.5 | 4.7 ± 0.8 |
| AD/HpScl | 20 | 86.7 ± 5.8 | 1104 ± 143 | 5.5 ± 0.6 | 5.0 ± 0.0 |
| AD/HpScl+ | 24 | 87.3 ± 7.5 | 977 ± 181 | 5.7 ± 0.6 | 5.0 ± 0.0 |
| AD/Other | 21 | 80.9 ± 11.0 | 1032 ± 135 | 5.5 ± 0.6 | 4.8 ± 0.6 |
| AD/Other+ | 25 | 81.8 ± 10.6 | 950 ± 176 | 5.4 ± 0.7 | 4.6 ± 0.7 |
| Secondary AD | 15 | 79.5 ± 8.1 | 1075 ± 167 | 4.6 ± 0.9 | 4.4 ± 0.9 |
| No AD | 74 | 83.0 ± 7.7 | 1049 ± 167 | 2.9 ± 1.3 | 1.5 ± 1.7 |
| Normal | 5 | 87.6 ± 4.5 | 1140 ± 158 | 2.9 ± 0.2 | 1.4 ± 1.3 |