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. 2019 Jul 18;132(14):jcs232330. doi: 10.1242/jcs.232330

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 8. — Two-step chromosome segregation model and the role of SUMO. (A) During early anaphase, chromosomes begin to separate without MTs being present between them. This area is filled with BUB-1 and SUMO, among other proteins, suggesting that these proteins could play a role during this early segregation step. As anaphase progresses, MTs populate the region between segregating chromosomes leading to the CLS-2-dependent stage. (B) The dynamic composition of the ring domain and central spindle throughout anaphase is depicted.