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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Acta Biomater. 2018 Dec 31;85:282–293. doi: 10.1016/j.actbio.2018.12.051

Fig. 4.

Fig. 4.

Intraoperative image of the critical-sized defect created in rat maxillae (upper jaw) after extraction of the first molar tooth. (A) Defect drilled into the upper jaw bone (indicated by arrow), (B) Filling of defect with mineralized nanofiber graft, and (C) Suturing of the tissue around the defect to hold the graft in place. Representative 3D reconstructions of coronal (XZ) view micro-CT images of the defect (D) immediately after tooth extraction and defect creation, (E) Unfilled defect/control after 4 weeks, (F) Defect filled with mineralized PCG nanofiber fragments, and (G) Defects filled with E7-BMP-2 peptide-loaded mineralized PCG nanofiber fragments. The dashed circles indicate the region of the defect. (H) New bone volume fraction (%) and bone mineral density (g/cc), and (I) trabecular bone parameters (thickness, number, and separation) measured in the different experimental groups after 4 weeks of suturing the periodontal defects. Data shown are mean ± SD of n = 6 for each group. *p < 0.05.