Table 2. The risk score generated from the 3-mRNA signature as an independent indicator according to Cox proportional hazards regression model.

Factors	Subgroup	Univariate analysis			Multivariate analysis
		Hazard ratio	95% CI	p	Hazard ratio	95% CI	p
Age (year)	<50	1
	≥50, <60	0.8	0.4–1.5	0.516
	≥60, <70	1	0.5–1.8	0.925
	>70	1.6	0.9–3.0	0.125
Gender	Male	1
	Female	1.1	0.7–1.6	0.722
Race	White	1
	Asian	0.7	0.2–2.7	0.561
	Black or African American	1.9	0.9–3.9	0.086
Histologic grade	G1	1			1
	G2	1.7	0.9–3.2	0.121	1.3	0.7–2.6	0.405
	G3	2.2	1.1–4.5	0.035	1.8	0.9–3.8	0.111
	G4	0	0.0–Inf	0.996	0	0.0–Inf	0.996
Pathological stage	Stage I	1			1
	Stage II	1.5	0.3–7.3	0.604	1	0.1–13.6	0.986
	Stage III	3.4	0.8–14.4	0.1	2.3	0.2–27.8	0.518
	Stage IV	5.1	1.2–20.8	0.024	1.9	0.1–23.8	0.6636
Pathological T	T1	1			1
	T2	2.1	0.6–7.1	0.23	1.6	0.2–12.5	0.647
	T3	4.8	1.5–15.8	0.009	2.3	0.3–17.7	0.411
	T4	4.4	1.4–14.2	0.013	2.2	0.3–17.2	0.45
Pathological N	N0	1			1
	N1	0.9	0.5–1.8	0.813	0.6	0.3–1.3	0.217
	N2	2.2	1.4–3.3	<0.001	1.3	0.7–2.4	0.447
	N3	4.2	1.0–17.5	0.05	3.5	0.8–15.4	0.099
Risk scores	Low risk	1			1
	High risk	2.3	1.5–3.6	<0.001	1.9	1.2–2.9	0.004