Table 1.
Summary of articles
| Authors | Diagnosis | N (M/F) | Study | N e/c | Intervention | Outcome parameters | Period of follow-up | PEDro Score |
|---|---|---|---|---|---|---|---|---|
| Chen et al (2018)16 | OA | 50 (7M/43F) | NCT | 26/24 | Mesotharapy (lidocaine, piroxicam, calcitonin (acute phase) or procaine, organic silica (chronic phase) vs oral diclofenac | WOMAC for pain, stiffness, and function | T0: baseline T1: after 6 months |
5/10 |
| Genc-Koyucu et al (2018)20 | LBP* | 168 (168F) | RCT | 84/84 | Mesotherapy with sterile water vs dry mesotherapy | VAS for pain; a satisfaction scale; IBFAT for infant breastfeeding | T0: baseline T1: after 10 min T2: after 30 min T3: after 60 min T4: after 120 min T5: after 180 min |
8/10 |
| Paolucci et al (2016)18 | CNP | 42 (18M/24F) | RS | 22/20 | Mesotherapy with local anesthetic lidocaine hydrochloride vs dry mesotherapy | VAS for pain; NDI for perceived pain and disability; VRS for pain; SF-12 for quality of life | T0: baseline T1: end of treatment T2: after 3 months |
7/10 |
| Yang et al (2018)19 | ANP | 36 (15M/21F) | RCT | 18/18 | Mesotherapy with local anesthetic and steroid vs oral ibuprofen | VAS for pain; NDI for perceived pain and disability; PGIC for patient’s belief | T0: baseline T1: after 3 hrs T2: after 1 day T3: after 3 days |
8/10 |
| Saggini et al (2015)17 | OA | 117 (59M/58F) | RCT | 60/57 | Mesotherapy with sodium diclofenac vs oral sodium diclofenac | VAS for pain; KOOS for knee function | T0: baseline T1: end of treatment T2: after 1 month T3: after 3 months |
8/10 |
| Ferrara et al (2017)22 | CSP | 217 (55M/162F) | RS | 110/107 | Mesotherapy with drug cocktail (normal saline solution, lidocaine hydrochloride, lysine acetylsalicylate) vs mesotherapy with normal saline solution | VAS and McGill for pain | T0: baseline T1: end of the treatment program T2: after 4 weeks T3: after 12 weeks |
7/10 |
| Cui et al (2016)21 | ALBP | 68 (27M/41F) | RCT | 34/34 | Mesotherapy with sterile water vs mesotherapy with isotonic saline | VAS for pain; Patient-specific functional scale for functional status; Global rating of change for patients’ global impression | T0: baseline T1: after 10 min T2: after 45 min T3: after 90 min T4: after 1 day |
8/10 |
Abbreviations: WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index; VAS, visual analog scale; IBFAT, Infant Breastfeeding Assessment Tool; NDI, Neck Disability Index; VRS, Verbal Rating Scale; SF-12, Short Form-12 Health Survey; PGIC, Patient Global Impression of Change; KOOS, Knee Injury and Osteoarthritis Outcome Score; OA, osteoarthritis; LBP, low back pain; CNP, chronic neck pain; ANP, acute neck pain; CSP, chronic spinal pain; ALBP, acute low back pain; N, number of samples; E, experimental; C, control; M, male; F, female; LBP*, low back pain in labor; RCT, randomized controlled trial; NCT, nonrandomized controlled trial; RS, retrospective study.