Table 1.
Molecular and viral diagnosis. Results of different tests for possible perinatal infections associated with congenital abnormalities according to the different trimesters
| Test | First case | Second case | ||||
|---|---|---|---|---|---|---|
| First trimester | Second trimester | Third trimester | First trimester | Second trimester | Third trimester | |
| ZIKV positive results | ||||||
| In blood and amniotic liquid | Positive | Positive | ||||
| In blood only | Positive | Positive | Positive | Negative | ||
| In amniotic liquid only | Positive | Positive | Positive | |||
| TORCH | ||||||
| Toxoplasmosis | ||||||
| Toxoplasma IgG | Positive | Positive | Positive | Negative | Negative | Negative |
| Toxoplasma IgM | Negative | Negative | Negative | Negative | Negative | Negative |
| Syphilis | ||||||
| RPR Serology | Negative | Negative | Negative | Negative | Negative | Negative |
| HIV | Negative | Negative | Negative | Negative | Negative | Negative |
| Rubella | ||||||
| Rubeola IgG | Positive | Positive | Positive | Positive | Positive | Positive |
| Rubeola IgM | Negative | Negative | Negative | Negative | Negative | Negative |
| CMV | ||||||
| CMV IgG | Negative | Negative | Positive | |||
| CMV IgM | Negative | Negative | Negative | |||
| Dengue | ||||||
| Dengue IgG | Negative | Negative | ||||
| Dengue IgM | Negative | Negative | ||||
| Chikungunya | ||||||
| Chikungunya IgG | Negative | Negative | ||||
| Chikungunya | Negative | Negative | ||||
| Parvovirus B19 | Negative | Negative | ||||
| Herpes simplex 1 and 2 | Negative | Negative | ||||
| Hepatitis B antibodies HBS | Negative | Negative | Negative | Negative | Negative | Negative |
| Karyotype | 46, XX | 46, XY | ||||
Abbreviations: ZIKV, Zika virus; RA, retinoic acid.