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. 2019 Jul 30;14:5849–5863. doi: 10.2147/IJN.S212260

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© 2019 Wang et al.

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Histological features of the skin treated with different formulations in AD mouse model. The sections were stained with hematoxylin and eosin (A) and toluidine blue (B), respectively.

Abbreviations: AD, atopic dermatitis; DNCB, 1–chloro–2,4–dinitrobenzene; FK506, tacrolimus; Control, healthy mice with shaved dorsal region; DNCB, AD-induced mice without drug treatment; DNCB + PC, AD-induced mice treated with propylene carbonate containing 0.1% (w/v) FK506; DNCB + Ointment; AD-induced mice treated with commercial ointment containing 0.1% (w/w) FK506; DNCB + Oil free; AD-induced mice treated with Oil free containing 0.1% (w/v) FK506; DNCB + Vehicle, AD-induced mice treated with microemulsion based on menthol/camphor eutectic vehicle without FK506; DNCB + MCE ME, AD-induced mice treated with microemulsion based on menthol/camphor eutectic containing 0.1% (w/v) FK506; DNCB + MCE ME gel, AD-induced mice treated with microemulsion based on menthol/camphor eutectic gel containing 0.1% (w/w) FK506.