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. 2019 Jul 30;14:5849–5863. doi: 10.2147/IJN.S212260

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© 2019 Wang et al.

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Effects of different formulations on serum total IgE.

Notes: *P<0.05 in comparison with DNCB; **P<0.001 in comparison with DNCB; ^#P<0.05 in comparison with DNCB + Ointment; ^##P<0.001 in comparison with DNCB +Ointment; ⁺P<0.05; ⁺⁺P<0.001.

Abbreviations: AD, atopic dermatitis; DNCB, 1–chloro–2,4–dinitrobenzene; FK506, tacrolimus; Control, healthy mice with shaved dorsal region; DNCB, AD-induced mice without drug treatment; DNCB + PC, AD-induced mice treated with propylene carbonate containing 0.1% (w/v) FK506; DNCB + Ointment: AD-induced mice treated with commercial ointment containing 0.1% (w/w) FK506; DNCB + Oil free, AD-induced mice treated with Oil free containing 0.1% (w/v) FK506; DNCB + Vehicle, AD-induced mice treated with microemulsion based on menthol/camphor eutectic vehicle without FK506; DNCB + MCE ME, AD-induced mice treated with microemulsion based on menthol/camphor eutectic containing 0.1% (w/v) FK506; DNCB + MCE ME gel, AD-induced mice treated with microemulsion based on menthol/camphor eutectic gel containing 0.1% (w/w) FK506; SD, standard deviation.