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. 2019 Jul 30;14:5785–5797. doi: 10.2147/IJN.S213974

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© 2019 Fang et al.

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(A) 4T1 tumor-bearing mice were administered PBS, DOX, NH₂-MSNs, HA-MSNs, DOX-NH₂-MSNs or DOX-HA-MSNs every 3 days for 22 days via intravenous injection. (B) The body weights of PBS-treated mice compared with mice treated with NH₂-MSNs, HA-MSNs, DOX-NH₂-MSNs, and DOX-HA-MSNs and free DOX over the 22 days, (C) the tumor volumes in the six groups, (D) photographs of the tumors on day 22 and (D) the tumor weights on day 22. Data are the mean values ± SD, *p<0.05 and **p<0.01versus the control group.