Table 1. Comparison of serum levels of bone metabolism biomarkers in patients with PDB and in controls with primary osteoarthritis.
RANKL - receptor activator of nuclear factor kappa-Β ligand, DKK-1 - Dickkopf-related protein-1, sFRP-1 - soluble frizzled-related protein 1, PDB - Paget’s disease of bone, OPG - osteoprotegerin
| Controls (n = 24) | PDB with active disease (n = 39) | p value | |
| RANKL (pg/ml) | 24.69 (8.00) | 110.27 (214.40) | p = 0.061 |
| Osteoprotegerin (pg/ml) | 281.71(241.34) | 278.60 (328.49) | p = 0.969 |
| DKK-1 (pg/ml) | 965.61(1007.63) | 916.98 (921.26) | p = 0.847 |
| sFRP-1 (pg/ml) | 27.28 (16.67) | 27.23 (40.07) | p = 0.951 |
| Sclerostine (pg/ml) | 12.24 (6.20) | 12.25 (6.80) | p = 0.992 |
| Osteopontin (pg/ml) | 2201.33 (2156.49) | 6724.19 (6366.32) | p = 0.002 |
| RANKL/Opg | 0.973 (2.14) | 3.42 (7.06) | p = 0.119 |