Fig. 7.

Ordered behaviors originate from lamellipodia that turn over very frequently. In all cases, the front adhesion region with θ_F = 180° is divided into 6 sections, and only one of them can be activated at once for up to T_F = 6 min. Cell density is 2300 cells/mm². a, b Time evolution of order parameters measured for the polarity and velocity of cells depending on sensitivity to contact. Numbers in the legends represent the sensitivity of lamellipodia to contact. Ordered behaviors are more apparent with higher sensitivity to contact. c, d Asymptotic values of ordered parameters for the polarity and velocity of cells, averaged over last 6 hours depending on the duration and sensitivity of lamellipodia. Numbers in the legends indicate the duration of lamellipodia (T_F). Higher sensitivity to contact or shorter duration (i.e. fast turnover of lamellipodia) leads to more ordered behaviors