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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Cell Stem Cell. 2019 Jun 13;25(2):185–192.e3. doi: 10.1016/j.stem.2019.05.018

Figure 2. Antibody conditioned animals have intact immune systems and display tolerance to matched organ grafts.

Figure 2

(a-b) Abundance of host Vβ6 + T cells in peripheral blood following (a) WBM and (b) LSK haploidentical transplantation (pooled data from two replicate experiments, pooled, n=2–10). (c) Fetal heart into ear transplantation schematic. (d) Kaplan-Meier curve showing donor heart survival in haploidentical chimeras (n=5). (e) Gross examination, H&E, and IF of representative HSC-donor and 3rd party heart tissue in ears at 34 days following tissue transplant in haploidentical chimeras. (f) Anti-KLH IgG production following KLH immunization six (first challenge) and eight (second challenge) weeks after fully-MHC mismatched HSC transplantation (n=5). Data in (d) was subjected to a log-rank (Mantel-Cox) test and yielded P = 0.0002. Data and error bars in (f) represent means ± SD and one way ANOVA was performed where ****P≤0.0001.