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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: J Cancer Surviv. 2019 Jun 26;13(4):570–579. doi: 10.1007/s11764-019-00776-8

Table 3.

Multivariable models for associations between cancer treatment, chronic conditions and cognitive and HRQOL outcome

Verbal reasoning Word reading Mathematics Sustained
attention		 Long-term
verbal memory		 Verbal fluency HRQOL General
health
Est. P-val Est. P-val Est. P-val Est. P-val Est. P-val Est. P-val Est. P-val
Ridge
regression		 Dactinomycin 0.001 0.91 0.010 0.056 0.018 0.086 0.013 0.36 0.072 0.014 0.004 0.77 0.058 0.62
Vincristine −0.0001 0.95 0.0003 0.75 −0.001 0.65 −0.001 0.78 −0.010 0.20 0.001 0.81 0.007 0.62
Doxorubicin −0.0002 0.54 −0.0003 0.15 −0.001 0.12 −0.0002 0.76 −0.002 0.11 −0.0004 0.49 −0.0003 0.74
Radiation
   Radiation to abdomen 0.090 0.28 −0.019 0.66 0.14 0.097 −0.13 0.28 0.55 0.0062 0.12 0.30 −0.16 0.45
   Radiation to abdomen and chest 0.021 0.84 0.028 0.62 0.019 0.86 0.20 0.21 0.46 0.070 0.40 0.0073 −0.73 0.004
Chronic conditions
Grade 2–4
Generalized linear
models		 Cardiovascular system 0.076 0.70 0.13 0.19 0.014 0.93 0.32 0.19 0.012 0.96 −0.10 0.59 −0.34 0.081
Respiratory system 0.080 0.67 0.054 0.59 0.022 0.89 0.18 0.45 0.23 0.30 0.20 0.28 −0.23 0.22
Reproductive system −0.13 0.52 −0.041 0.70 0.123 0.47 0.15 0.56 −0.051 0.83 −0.17 0.39 −0.46 0.021
Endocrine system −0.34 0.053 −0.11 0.25 −0.26 0.084 0.15 0.52 −0.23 0.27 −0.15 0.39 −0.44 0.012
Renal system 0.45 0.11 0.023 0.88 0.25 0.29 −0.23 0.51 0.28 0.40 0.25 0.37 −0.66 0.016
Musculoskeletal system 0.12 0.54 −0.015 0.88 0.044 0.78 −0.56 0.016 0.083 0.70 −0.061 0.74 −0.21 0.25
Neurology system −0.44 0.052 −0.18 0.15 −0.30 0.11 −0.73 0.010 −0.78 0.0025 −0.27 0.22 −0.80 <0.001
Second neoplasms (Yes) 0.49 0.10 0.24 0.13 0.25 0.33 0.41 0.29 0.22 0.55 0.22 0.46 0.22 0.46

Ridge regression models for treatment variables, generalized linear models for chronic conditions. Separate models for each cognitive outcome variable. Chemotherapy and radiation in the same models, chronic conditions in separate models. Non-standardized estimates. Cognitive measures in z-scores. Chemotherapy per mg/m2. Radiation as compared to no radiation. All models adjusted for sex, race/ethnicity and time since diagnosis. Bold type indicates significant models.