Table 2.

Longitudinal associations between liver scores’ risk classes at baseline and incidence of overall and cause-specific mortality and disability at 6 years’ follow-up.

	NFS		FIB-4		BARD		AST/ALT ratio
	HR (95%CI)	aHR (95%CI)	HR (95%CI)	aHR (95%CI)	HR (95%CI)	aHR (95%CI)	HR (95%CI)	aHR (95%CI)
Overall M
Low risk	ref	ref	ref	ref	ref	ref	ref	ref
Interm risk	1.64 (1.2–2.24)	1.78 (1.29–2.47)	1.51 (1.16–1.96)	1.34 (1.02–1.77)	2.43 (1.38–4.27)	1.49 (0.81–2.72)	1.8 (1.07–3.04)	2.02 (1.19–3.44)
High risk	2.14 (1.64–2.78)	1.6 (1.21–2.1)	2.86 (2.12–3.85)	2.02 (1.47–2.77)	2.9 (1.55–5.42)	1.81 (1.10–2.93)	2.61 (1.61–4.22)	1.74 (1.06–2.86)
CV mortality
Low risk	ref	ref	ref	ref	ref	ref	ref	ref
Interm risk	2.32 (1.47–3.67)	2.9 (1.8–4.66)	1.96 (1.33–2.9)	1.76 (1.17–2.64)	2.21 (0.9–5.41)	0.97 (0.38–2.46)	1.53 (0.62–3.77)	1.15 (0.46–2.86)
High risk	3.24 (2.2–4.77)	2.42 (1.61–3.64)	3.57 (2.27–5.62)	2.22 (1.36–3.6)	3.29 (1.25–8.66)	1.23 (0.45–3.38)	3.34 (1.47–7.59)	1.27 (0.54–2.96)
	RR (95%CI)	aRR (95%CI)	RR (95%CI)	aRR (95%CI)	RR (95%CI)	aRR (95%CI)	RR (95%CI)	aRR (95%CI)
Disability at 6 y*
Low risk	ref	ref	ref	ref	ref	ref	ref	ref
Interm risk	1.39 (0.64–2.7)	1.37 (0.62–2.71)	1.3 (0.69–2.32)	1.3 (0.68–2.35)	6.25 (1.38–110.5)	2.80 (0.60–49.9)	1.64 (0.52–7.2)	1.31 (0.42–5.79)
High risk	2.04 (1.11–3.57)	1.93 (1.13–2.93)	3.69 (1.95–6.57)	2.76 (1.38–5.19)	5.8 (1.06–107.6)	2.33 (0.40–44.2)	3.41 (1.26–13.98)	1.49 (0.53–6.23)

Adjusted(a-) models corrected for age, sex, body mass index, arterial hypertension, diabetes mellitus, chronic obstructive pulmonary disease, congestive heart failure, total cholesterol, Charlson comorbidity index, physical activity, alcohol consumption, smoke, IL-6 and TNF-alpha. Age was not considered in models with NFS and FIB4 and diabetes mellitus and body mass index were not considered in models with NFS and BARD, because already included in the liver scores, themselves.

^*Disable patients (N 49) at baseline were excluded.