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. 2019 Aug 1;7:e7413. doi: 10.7717/peerj.7413

Table 3. Stratified analysis of the overall survival of four-lncRNA signature in the training set and testing set.

Variable Training set Testing set
Number HR P Number HR P
(High/Low) (95% CI) value (High/Low) (95% CI) value
Gender
Female 6/7 3.939 (0.409–37.96) 0.2 6/7 4.037 (0.365–44.68) 0.22
Male 45/45 3.603 (1.668–7.781) 0.0005* 38/49 2.405 (1.312–4.408) 0.0034*
Age
<60 45/35 3.536 (1.512–8.27) 0.0019* 34/47 2.412 (1.269–4.584) 0.0056*
≥60 6/17 4.253 (0.946–19.11) 0.059 10/9 7.153 (0.858–59.62) 0.069
ALT
≤50 U/L 27/34 2.985 (1.325–6.726) 0.0056* 22/32 2.479 (1.047–5.868) 0.033*
>50 U/L 24/18 10.87 (1.386–85.23) 0.0045* 22/24 2.358 (1.056–5.269) 0.032*
Main Tumor Size
≤5 cm 32/36 5.949 (1.963–18.02) 0.00036* 21/37 2.145 (0.993–4.637) 0.0523
>5 cm 18/16 2.213 (0.825–5.94) 0.11 23/19 2.5 (0.992–6.298) 0.0519
Multinodular
NO 39/47 4.157 (1.834–9.419) 0.00021* 30/44 3.017 (1.472–6.183) 0.0015*
YES 12/5 1.575 (0.316–7.857) 0.58 14/12 0.641 (0.231–1.777) 0.39
TNM stage
I+II 37/45 4.186 (1.633–10.73) 0.0012* 24/47 2.779 (1.337–5.778) 0.0043*
III 14/7 1.778 (0.555–5.693) 0.33 19/8 1.454 (0.503–4.206) 0.49
BCLC stage
0+A 36/47 4.728 (1.858–12.03) 0.00033* 26/43 3.238 (1.481–7.08) 0.0019*
B+C 15/5 0.879 (0.275–2.816) 0.83 17/12 0.630 (0.252–1.575) 0.32
AFP
≤300 ng/ml 21/33 3.944 (1.446–10.76) 0.0039* 17/35 4.625 (1.842–11.61) 0.00037*
>300 ng/ml 29/17 3.012 (1.004–9.033) 0.039* 27/21 1.438 (0.659–3.136) 0.36

Notes.

*

Statistically significant.

Abbreviations

BCLC stage
Barcelona Clinic Liver Cancer stage
Multinodular
whether the tumor has multiple nodules
HR
hazard ratio
95% CI
95% confidence interval