Table 3. Stratified analysis of the overall survival of four-lncRNA signature in the training set and testing set.
| Variable | Training set | Testing set | ||||
|---|---|---|---|---|---|---|
| Number | HR | P | Number | HR | P | |
| (High/Low) | (95% CI) | value | (High/Low) | (95% CI) | value | |
| Gender | ||||||
| Female | 6/7 | 3.939 (0.409–37.96) | 0.2 | 6/7 | 4.037 (0.365–44.68) | 0.22 |
| Male | 45/45 | 3.603 (1.668–7.781) | 0.0005* | 38/49 | 2.405 (1.312–4.408) | 0.0034* |
| Age | ||||||
| <60 | 45/35 | 3.536 (1.512–8.27) | 0.0019* | 34/47 | 2.412 (1.269–4.584) | 0.0056* |
| ≥60 | 6/17 | 4.253 (0.946–19.11) | 0.059 | 10/9 | 7.153 (0.858–59.62) | 0.069 |
| ALT | ||||||
| ≤50 U/L | 27/34 | 2.985 (1.325–6.726) | 0.0056* | 22/32 | 2.479 (1.047–5.868) | 0.033* |
| >50 U/L | 24/18 | 10.87 (1.386–85.23) | 0.0045* | 22/24 | 2.358 (1.056–5.269) | 0.032* |
| Main Tumor Size | ||||||
| ≤5 cm | 32/36 | 5.949 (1.963–18.02) | 0.00036* | 21/37 | 2.145 (0.993–4.637) | 0.0523 |
| >5 cm | 18/16 | 2.213 (0.825–5.94) | 0.11 | 23/19 | 2.5 (0.992–6.298) | 0.0519 |
| Multinodular | ||||||
| NO | 39/47 | 4.157 (1.834–9.419) | 0.00021* | 30/44 | 3.017 (1.472–6.183) | 0.0015* |
| YES | 12/5 | 1.575 (0.316–7.857) | 0.58 | 14/12 | 0.641 (0.231–1.777) | 0.39 |
| TNM stage | ||||||
| I+II | 37/45 | 4.186 (1.633–10.73) | 0.0012* | 24/47 | 2.779 (1.337–5.778) | 0.0043* |
| III | 14/7 | 1.778 (0.555–5.693) | 0.33 | 19/8 | 1.454 (0.503–4.206) | 0.49 |
| BCLC stage | ||||||
| 0+A | 36/47 | 4.728 (1.858–12.03) | 0.00033* | 26/43 | 3.238 (1.481–7.08) | 0.0019* |
| B+C | 15/5 | 0.879 (0.275–2.816) | 0.83 | 17/12 | 0.630 (0.252–1.575) | 0.32 |
| AFP | ||||||
| ≤300 ng/ml | 21/33 | 3.944 (1.446–10.76) | 0.0039* | 17/35 | 4.625 (1.842–11.61) | 0.00037* |
| >300 ng/ml | 29/17 | 3.012 (1.004–9.033) | 0.039* | 27/21 | 1.438 (0.659–3.136) | 0.36 |
Notes.
Statistically significant.
Abbreviations
- BCLC stage
- Barcelona Clinic Liver Cancer stage
- Multinodular
- whether the tumor has multiple nodules
- HR
- hazard ratio
- 95% CI
- 95% confidence interval