KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Olig2	Millipore	Cat# AB9610; RRID:AB_570666
CC1	Calbiochem	Cat# OP80; RRID:AB_2057371
PDGFRα	Santa Cruz Biotechnology	Cat# SC-338; RRID:AB_631064
GFAP	Cell Signaling Technology	Cat# 3670; RRID:AB_561049
Iba-1	Wako	Cat# 019–19744; RRID: AB_839504
NeuN	Abcam	Cat# Ab177487; RRID:AB_2532109
c-Fos	Abcam	Cat# Ab7693; RRID: AB_306177
phosphorylated PKA	Santa Cruz Biotechnology	Cat# SC-32968; RRID:AB_2237593
PKA	Santa Cruz Biotechnology	Cat# SC-98951; RRID:AB_2170328
GAPDH	Proteintech	Cat# 60004–1-lg; RRID: AB_2107436
POMC	Phoenix Pharmaceuticals	Cat# H-029–30; RRID:AB_2307442
AGRP	R&D Systems	Cat# AF634; RRID:AB_2273824
phosphorylated STAT3	Cell Signaling Technology	Cat# 9131; RRID:AB_331586
STAT3	Cell Signaling Technology	Cat# 12640; RRID:AB_2629499
phosphorylated AKT	Cell Signaling Technology	Cat# 4060; RRID:AB_2315049
AKT	Cell Signaling Technology	Cat# 9272; RRID:AB_329827
PDK1	Cell Signaling Technology	Cat# 3820; RRID:AB_1904078
phosphorylated PDH	Abcam	Cat# ab177461; RRID:AB_2756339
PDH	Cell Signaling Technology	Cat# 3205; RRID:AB_2162926
MBP	Biolegend	Cat# 808401; RRID:AB_2564741
NG2	Millipore	Cat# AB5320; AB_11213678
Parvalbumin	Abcam	Cat# ab11427; RRID:AB_298032
Critical Commercial Assays
cAMP-Glo Assay Kit	Promega	Cat# V1501
L-lactate assay kit	Biovision	Cat# K627–100
Deposited Data
Original pictures	This paper	DOI: https://data.mendeley.com/datasets/wdmx6trhnr/4
Experimental Models: Organisms/Strains
Gt(ROSA)26Sortm1(CAG-CHRM4*,-mCitrine)Ute/J mice	Jackson laboratory	Cat# 026219
Gt(ROSA)26Sortm9(CAG-tdTomtao)Hze mice	Kindly provided by Dr. Liang Zhang (Xiamen University)	N/A
Gpr17−/− mice	Chen et, al. 2009	N/A
Olig1cre/+;Gpr17fl/fl mice	Ou et, al. 2016	N/A
C57BL/6 mice	Xiamen University Laboratory Animal Center	N/A
Sprague-Dawley rats	Xiamen University Laboratory Animal Center	N/A