Skip to main content
. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Drug Target. 2019 Feb 4;27(5-6):690–698. doi: 10.1080/1061186X.2019.1566339

Figure 1. Physiologically based multicompartmental model of tumor targeting:

Figure 1.

The model consists of blood, endothelium and extravascular compartments and respective rates (k). The full list of differential equations is provided in the Methods section. The extravascular compartment consists of multiple layers, and the diffusion rates are assumed to be equal in all directions. The number of extravascular layers in the model is arbitrarily set to 4 in the model (only 2 are shown here) and does not affect net tumor accumulation. The volumes of compartments were calculated based on the values reported in the literature (see Results).