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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Drug Target. 2019 Feb 4;27(5-6):690–698. doi: 10.1080/1061186X.2019.1566339

Figure 2. Algorithm for describing pharmacokinetic profile of non-targeted nanoparticles with the model:

Figure 2.

A) simplified schematic of the PK model (based on Fig. 1) shows compartments used in each step; B) actual data for targeted nanoparticles (Table 1) were plotted as %ID/g over time (green circles). Each step corresponds to the schematic above. The tumor profile cannot be described by EIR only, as nanoparticles rapidly wash out (left graph, red line); addition of ITDR improves the profile, but nanoparticles are still being washed out from the tumor (center graph, purple dashed line); addition of EVB into the model achieves a good correlation with the data (right graph, green line).