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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Drug Target. 2019 Feb 4;27(5-6):690–698. doi: 10.1080/1061186X.2019.1566339

Figure 3. Algorithm for describing pharmacokinetic profile of endothelium-targeted nanoparticles with the model:

Figure 3.

A) Profile for endothelium-targeted nanoparticles was described by using EIR, ITDR and EVB for non-targeted nanoparticles (Fig. 2B) and adding IVB; B) actual and simulated profiles for non-targeted and targeted nanoparticles. Note that intravascular targeting increases the rate of nanoparticle accumulation in the tumor.