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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Drug Target. 2019 Feb 4;27(5-6):690–698. doi: 10.1080/1061186X.2019.1566339

Figure 4. Sensitivity of the AUC to changes in EIR, ITDR, EVB and IVB:

Figure 4.

The parameters were changed one at a time and the percent change of AUCT was plotted on the Y-axis. A) Effect of EIR and ITDR on AUCT. EVB was set to 0.82 and IVB was set to 0. Arrow points to the set of parameters for non-targeted SWNT-PEG5000 found in Fig. 2. The model is not very sensitive in the range of lower EIR and ITDR values, but becomes sensitive in the range of higher values; B) Effect of EVB and IVB on AUCT. EIR and ITDR were set to 0.018 and 0.022, respectively. Arrow points to the set of parameters for non-targeted SWNT-PEG5000. The model is not sensitive to changes in EVB but very sensitive to changes in IVB, suggesting that intravascular targeting is a more efficient process than extravascular targeting.