Skip to main content
. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Drug Target. 2019 Feb 4;27(5-6):690–698. doi: 10.1080/1061186X.2019.1566339

Figure 5. Simulations of tumor accumulation efficiency of non-targeted versus extravascular-targeted nanoparticles:

Figure 5.

A) Extravascular targeting was simulated as an increase in EVB from 0.82 to 4.0. Arrow points to the original settings of non-targeted SWNT-PEG5000. Increasing either EIR or ITDR alone minimally improves the accumulation of non-targeted and targeted nanotubes, while increasing both EIR and ITDR increases the accumulation of non-targeted and targeted SWNTs; B) Increasing circulation half-life has a major effect on AUCT of non-targeted and extravascular-targeted nanotubes. Red line: EVB 4.0; blue line: EVB 0.82. Arrow points to the original settings of non-targeted SWNT-PEG5000.