Skip to main content
. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Drug Target. 2019 Feb 4;27(5-6):690–698. doi: 10.1080/1061186X.2019.1566339

Fig. 6. Simulation of distribution of nanoparticles between tumor layers as function of EIR, ITDR and EVB:

Fig. 6.

A) Accumulation profile of nanoparticles in tumor layers (concentration in arbitrary units) using settings for non-targeted SWNT-PEG5000; B) Relative concentrations of non-targeted (EVB 0.82) and extravascular-targeted (EVB 4.0) nanoparticles in tumor layers at 2500 min. Legend is the same as in A. Targeted nanoparticles showed decreased tumor penetration (binding site barrier), likely due to the first layer serving a “trap” for nanoparticles; C) Combined effect of EIR, ITDR and EVB on accumulation in tumor layers. At low extravasation and diffusion rates, increasing EVB decreases concentration in deeper layers. Increasing both EIR and ITDR 10-fold increases the concentration of nanoparticles in all layers. Note that increasing EVB 5-fold further increases accumulation in al layers, but the binding site effect is still there.