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The major pathways and the pharmacological treatments targeting them. ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; ET, endothelin; GTP, guanosine triphosphate; GMP, guanosine monophosphate; IP, I-prostanoid receptors; NO, nitric oxide; PDE-5, phosphodiesterase type 5; sGC, soluble guanylate cyclase. Adapted with permission from Prior et al. update on pharmacotherapy for pulmonary hypertension, Med J Aust 2016. 86
