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. 2019 Jul 23;52(4):306–313. doi: 10.5946/ce.2019.056

Table 2.

Ability of Contrast-Enhanced Harmonic Endoscopic Ultrasound in Estimating the Malignancy Potential GIST

Study Number of subjects Location of lesion Diameter of lesion (mm) (mean) Contrast agent Diagnostic test performance Findings suspicious of malignancy
Sakamoto et al. (2011) [15] Japan 29 Stomach- 22 Low-grade: 29 Sonazoid® (15 μL/kg) Grade malignant potential:
Duodenum- 7 High-grade: 32 Abnormal vessel visualization and heterogeneous enhancement
Sensitivity- 100%, Specificity- 63%, Accuracy- 83%
Yamashita et al. (2015) [13] Japan 13 Stomach- 12 Low-grade: 24 Sonazoid® (0.7 mL) Grade malignant potential:
Duodenum- 1 High-grade: 62 Abnormal vessel visualization
Sensitivity- 100%, Specificity- 87.5%, Accuracy- 92.3%
Park et al. (2016) [14] Korea SET- 35 Stomach- 26 Low-grade: 28 SonoVue® (2.4 mL) Grade malignant potential:
GIST- 26 Esophagus- 3 High-grade: 43 Non-enhancing spot
Duodenum- 3 Sensitivity- 63.6%, Specificity- 53.3%, Accuracy- 57.6%
Rectum- 3

GIST, gastrointestinal stromal tumor; SET, subepithelial tumor.

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