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. 2019 Aug 5;10(8):584. doi: 10.1038/s41419-019-1821-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a All sequenced melanoma cell lines show significant differences in gene expression due to the regulatory activity of c-Jun compared to NHEMs. Violin blots display the interquartile ranges (25–75%) with an intersection as the median; Significantly different distributions in pairwise comparisons are indicated (****P < 0.0001, Wilcoxon test, two-sided). b Clustering of c-Jun peak sets by PTEN expression status revealed a correlation between c-Jun activity and PTEN expression. c Heat maps and histograms of ChIP-Seq tag counts of the histone acetylation status (H3K27ac) in a 5-kb wide range around c-Jun peaks. Regions centered on c-Jun-bound regions were clustered according to their H3K27ac ChIP-Seq profiles in melanoma and NHEMs, illustrating a high acetylation rate around the genomic c-Jun peaks in melanoma and a low rate in NHEMs (****P < 0.0001, Wilcoxon test, paired, two-sided)