Table 1.
DAVID functional annotation analysis. Functional annotation analysis of RNA-Seq data via DAVID of the five generated gene sets (NHEM vs. PTENWT, PTENHemDel, PTENHomDel, PTENWTc-Jun or PTENHemDelc-Jun) depicting similar results in terms of enriched KEGG pathways
| total diffgenes | ||
|---|---|---|
| KEGG pathway | Size | P-value |
| NHEM-PTENWT | ||
| Pathways in cancer | 114 | 3.23E-05 |
| PI3K-Akt signaling pathway | 90 | 7.94E-03 |
| Rap1 signaling pathway | 71 | 6.23E-06 |
| Focal adhesion | 68 | 2.43E-05 |
| Endocytosis | 68 | 1.69E-02 |
| Proteoglycans in cancer | 67 | 1.66E-05 |
| Ras signaling pathway | 62 | 9.68E-03 |
| Lysosome | 61 | 5.40E-13 |
| NHEM-PTENHemDel | ||
| Pathways in cancer | 88 | 1.97E-06 |
| PI3K-Akt signaling pathway | 66 | 4.05E-03 |
| HTLV-I infection | 57 | 1.95E-04 |
| Rap1 signaling pathway | 55 | 2.00E-06 |
| Lysosome | 51 | 4.36E-14 |
| Focal adhesion | 49 | 1.14E-04 |
| Neuroactive ligand–receptor interaction | 49 | 4.92E-02 |
| Cytokine–cytokine receptor interaction | 48 | 2.79E-03 |
| NHEM-PTENHomDel | ||
| Pathways in cancer | 54 | 4.46E-02 |
| PI3K-Akt signaling pathway | 48 | 4.88E-02 |
| Rap1 signaling pathway | 39 | 7.93E-04 |
| Focal adhesion | 34 | 1.18E-02 |
| Axon guidance | 31 | 2.12E-05 |
| Lysosome | 26 | 9.01E-04 |
| Cell cycle | 24 | 5.99E-03 |
| Homologous recombination | 8 | 3.03E-02 |
| Other types of O-glycan biosynthesis | 8 | 4.24E-02 |
| diffgenes Jun | ||
|---|---|---|
| NHEM-PTENWT_Jun | ||
| Pathways in cancer | 45 | 3.59E-05 |
| PI3K-Akt signaling pathway | 35 | 2.76E-03 |
| Rap1 signaling pathway | 32 | 2.39E-06 |
| Focal adhesion | 31 | 4.63E-06 |
| Proteoglycans in cancer | 25 | 8.45E-04 |
| MAPK signaling pathway | 25 | 1.86E-02 |
| Endocytosis | 25 | 2.14E-02 |
| Ras signaling pathway | 24 | 8.73E-03 |
| NHEM-PTENHemDel_Jun | ||
| Pathways in cancer | 31 | 5.11E-04 |
| PI3K-Akt signaling pathway | 24 | 1.19E-02 |
| Rap1 signaling pathway | 20 | 7.85E-04 |
| Cytokine–cytokine receptor interaction | 20 | 2.30E-03 |
| Focal adhesion | 19 | 1.60E-03 |
| Ras signaling pathway | 18 | 9.70E-03 |
| cAMP signaling pathway | 17 | 6.17E-03 |
| Hippo signaling pathway | 15 | 3.02E-03 |