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. 2019 Aug 5;10(8):581. doi: 10.1038/s41419-019-1815-7

Fig. 5. Lentivirus-mediated PRMT3 downregulation leads to osteopenia phenotype in mice.

Fig. 5

a Micro-CT image of the femurs from Prmt3 shRNA treatment mice. Scale bar: 1 mm. b Quantitative measurements of bone mineral density (BMD), bone volume/tissue volume (BV/TV), trabecular thickness (Tb.Th), and trabecular spacing (Tb.Sp). Data are shown as mean ± SD; n = 5; *P < 0.05 by Student’s t-tests. c H&E staining of femur bone sections. Scale bar for 4×: 500 μm; Scale bar for 10×: 200 μm. d IHC staining for OCN, RUNX2, and PRMT3 of bone sections from Prmt3 shRNA treatment mice. Scale bar: 20 μm. Red arrows indicate positive staining