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. 2019 Jun 28;203(4):1076–1087. doi: 10.4049/jimmunol.1801472

FIGURE 2.

FIGURE 2.

LILRB1 marks CD8+ cells with higher effector molecule expression. (A) Representative dot plots show LILRB1 coexpression with perforin (left panel) and granzyme B (GZMB, right panel) in gated CD8+ T cell by ex vivo FACS analysis. (B) Quantitation of perforin (left panel) and GZMB (right panel) expression in LILRB1−CCR7− and LILRB1+CCR7− CD8+ subsets from multiple donors (n = 4). (C and D) Human CD8+ T cells from each donor were sorted into three subsets based on LILRB1 and CCR7 expression. Quantitation of effector molecules in supernatants were performed using a Luminex assay from resting (C) and TCR-activated (D) CD8+ T cell subsets after 48 h (n = 6). (E) Single-cell RNAseq results show differential gene expression between LILRB1+ and LILRB1− memory CD8+ T cells. *p < 0.05, paired Student t test.