IL-36γ inhibited H37Rv survival in MDMs through the noncanonical WNT pathway of WNT5A. (A and B) CFU assays of H37Rv loads in MDMs treated with rhWNT5A combined with or without BOX5 or XAV-939 (A), or treated with rhIL-36γ combined with or without rhWNT5A, BOX5, or XAV-939 (B). (C) Phosphorylation of JNK and NF-κB in H37Rv-infected MDMs treated with or without rhIL-36γ was analyzed using Western blot. Data presented are from one of least three independent experiments with similar results, and data are shown as means ± SD. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.