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. 2019 Jul 30;12:6083–6092. doi: 10.2147/OTT.S211560

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© 2019 Liang et al.

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Cisplatin activates the ATR-Chk1 pathway in chondrosarcoma cells. (A) Western blot analysis of the total and phosphorylated levels of basal ATR and Chk1 in untreated CS-1, SW1353, 5-8F, and JEG-3 cells. GAPDH protein levels were measured as loading controls. (B) Western blot analysis of the levels of total and phosphorylated ATR and Chk1 in CS-1 and SW1353 cells treated with 10 μM cisplatin for the indicated time periods. (C) Western blot analysis of the levels of total and phosphorylated ATR and Chk1 in CS-1 and SW1353 cells treated with the indicated concentrations of cisplatin for 24 h.