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. 2016 May 13;7(5):661–682. doi: 10.1002/wrna.1357

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© 2016 The Authors. WIREs RNA published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Schematic illustration of domains and motifs of important mammalian NMD factors. Amino acid numbering relates to the human proteins. All proteins are drawn to the same scale except for SMG1. CH: cysteine‐histidine rich domain; SQ: serine‐glutamine rich domain; MIF4G: middle of 4G‐like domains; UBD: UPF1‐binding domain; RRM: RNA recognition motif; EBM: exon junction binding motif; HEAT: Huntingtin, elongation factor 3 (EF3), https://en.wikipedia.org/wiki/Protein_phosphatase_2#Proteinphosphatase2A (PP2A), yeast kinase TOR1 domain; FAT: focal adhesion kinase domain; PIKK: phosphatidylinositol 3‐kinase‐related protein kinase domain; FATC: C‐terminal FAT domain; PIN: PilT N‐terminus domain; PC: C‐terminal proline‐rich region.