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. 2016 Dec 16;241(1):80–90. doi: 10.1002/path.4831

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© 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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PATH-4831-FIG-0006-c — CCL2 depletion attenuates monocytic infiltration and fibrotic changes after UUO. (A, B) Representative flow cytometry and quantitative analysis of renal CD11b⁺Ly6‐G⁻ macrophage staining in UUO model isotype antibody‐treated (isotype + UUO) and UUO model anti‐CCL2‐treated (anti‐CCL2 + UUO) mice 3 days after surgery. (C, D) Representative images and quantitative analysis of F4/80 staining in isotype + UUO and anti‐CCL2 + UUO mice 2 weeks after surgery. (E, F) Representative images and quantitative analysis of Masson's trichrome‐stained sections in isotype + UUO and anti‐CCL2 + UUO mice 2 weeks after surgery. Collagen is visible as the blue stain. (G, H) Representative images and quantitative analysis of Sirius red‐stained sections in isotype + UUO and anti‐CCL2 + UUO mice 2 weeks after surgery. Collagen is visible as the blue stain. Bar = 50 µm. *p < 0.05 versus isotype + UUO group. Data are presented as means ± SD (n = 6–8).