Table 4.
Resolution of ulcer‐related symptoms in study patients in the gastric ulcer and duodenal ulcer studiesa
| Symptom | GU study | DU study | ||||
|---|---|---|---|---|---|---|
| Vonoprazan | Lansoprazole | Difference (Von.−Lan.) | Vonoprazan | Lansoprazole | Difference (Von.−Lan.) | |
| Epigastric pain (postprandial) | ||||||
| N | 77 | 65 | 56 | 61 | ||
| Resolved, n (%) | 70 (90.9) | 61 (93.8) | −2.9 | 47 (83.9) | 53 (86.9) | −3.0 |
| 95% CI, lower, upper | 82.162, 96.266 | 84.987, 98.298 | −11.618, 5.744 | 71.672, 92.378 | 75.784, 94.164 | −15.774, 9.861 |
| Epigastric pain (fasting/nocturnal) | ||||||
| N | 120 | 118 | 116 | 123 | ||
| Resolved, n (%) | 109 (90.8) | 106 (89.8) | 1.0 | 98 (84.5) | 107 (87.0) | −2.5 |
| 95% CI, lower, upper | 84.190, 95.335 | 82.910, 94.634 | −6.507, 8.512 | 76.589, 90.536 | 79.737, 92.378 | −11.383, 6.365 |
| Abdominal distension | ||||||
| N | 42 | 44 | 59 | 38 | ||
| Resolved, n (%) | 39 (92.9) | 39 (88.6) | 4.2 | 48 (81.4) | 32 (84.2) | −2.9 |
| 95% CI, lower, upper | 80.517, 98.502 | 75.442, 96.206 | −7.969, 16.411 | 69.085, 90.308 | 68.747, 93.977 | −18.125, 12.415 |
| Nausea | ||||||
| N | 44 | 41 | 39 | 36 | ||
| Resolved, n (%) | 41 (93.2) | 37 (90.2) | 2.9 | 36 (92.3) | 34 (94.4) | −2.1 |
| 95% CI, lower, upper | 81.344, 98.571 | 76.869, 97.277 | −8.808, 14.684 | 79.130, 98.385 | 81.336, 99.320 | −13.359, 9.085 |
| Heartburn | ||||||
| N | 57 | 50 | 50 | 38 | ||
| Resolved, n (%) | 55 (96.5) | 41 (82.0) | 14.5 | 44 (88.0) | 33 (86.8) | 1.2 |
| 95% CI, lower, upper | 87.893, 99.572 | 68.563, 91.424 | 2.820, 26.162 | 75.690, 95.466 | 71.914, 95.586 | −12.865, 15.181 |
| Anorexia | ||||||
| N | 56 | 51 | 38 | 41 | ||
| Resolved, n (%) | 53 (94.6) | 43 (84.3) | 10.3 | 35 (92.1) | 36 (87.8) | 4.3 |
| 95% CI, lower, upper | 85.133, 98.881 | 71.412, 92.976 | −1.264, 21.922 | 78.623, 98.341 | 73.796, 95.919 | −8.884, 17.485 |
CI, confidence interval; DU, duodenal ulcer; GU, gastric ulcer.
a
This analysis includes all full analysis set patients who had gastrointestinal symptoms at the start of treatment.