Figure 3.

Distinct FEV₁pp-dependent stromal gene expression in samples from patients with or without cancer. (A) Distributions of intersections (i.e., for the regression slopes relating gene expression to FEV₁pp for subjects with cancer vs. subjects without cancer) for mRNAs with translational efficiencies or proteins with a low P value (P < 0.05) for the CFI. The dotted black line indicates the peak of the density. (B) Venn diagrams comparing genes that show FEV₁pp-dependent expression in subjects without cancer (P < 0.05, FEV₁pp) with those that show a CFI (P < 0.05, Interaction). (C–E) Heatmaps of slopes for the relationship between gene expression and FEV₁pp for subsets of genes from sectors of the Venn diagram. (A–E) The analysis was performed separately on translational efficiency (n = 32) and protein levels (n = 58). CFI = cancer status–FEV₁pp interaction; FEV₁pp = FEV₁ percent of the predicted value.