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. 2015 Apr 7;4(5):489–504. doi: 10.1002/wdev.190

Figure 1.

WDEV-190-FIG-0001-c

Schematic diagram of the cohesin complex. Cohesin is composed of four subunits. Smc1 and Smc3 (blue) are long polypeptides that form a hinge domain at one end and an ATPase domain at the other end by folding back on themselves to form antiparallel coiled‐coil interactions. The SMC heads are connected by the α‐kleisin RAD21 (green), which interacts with the fourth subunit, SA1 or SA2 (pink).